Careers

At Mersana, we all share a singular passion and vision: To dramatically improve the lives of people with cancer. We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun. 

If you share our passion to deliver an evolutionary leap in cancer patient care and our drive to tackle difficult challenges in a dynamic and collaborative environment, then please submit your resume or CV to careers@mersana.com.


ANALYTICAL CHEMISTRY

Principal/Senior Scientist, Protein Characterization ADC - mAb (CMC)

What’s in it for you?

In this role, you’ll have an opportunity to support the analytical characterization of Mersana’s Antibodies and ADCs within our CMC Analytical Chemistry group.  Since we are on the cutting edge of a new therapeutic category with its own unique testing requirements, we will take your existing expertise in analytical development, method development, validation/qualification and transfer, and complement it with our knowledge of polymer and small molecule chemistry.  You’ll also have an opportunity to form close partnerships with CMOs, CROs and internal stakeholders.  If you are passionate about our science and a curious scientist who enjoys being creative and not afraid to be challenged, this is a great opportunity to have an impact on Mersana’s unique novel platform.  We will work as a team to expand our knowledge base of our ADCs in order to enable their evolution towards optimized cancer therapies.  You will be immersed in a learning organization, with a need to bring an open mind and an interest in mastering this new therapeutic space at a rapid pace.   As part of a growing company you will have the potential to hire and mentor staff and build processes that will drive innovation, teamwork and efficiency within the organization. 

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Scientist/Senior Scientist, mAb & ADC Analytics

What’s in it for you?

In this role, you will be joining a growing organization working on cutting edge ADC technologies that present various interesting characterization challenges. You will have the opportunity to develop, troubleshoot, innovate and qualify analytical methods for complex biologics like ADCs. There will be ample opportunity for innovation by implementing new analytical methods, processes and learning new techniques. Our team strives for continuous learning and improvement, so you will not be dedicated to particular assays. Your great results and insights will drive decision-making in lead candidate selection, and you will be able to showcase results at relevant conferences. As one of the scientists on the Platform Discovery team, your decisions will influence the analytical strategies that we pursue. As the team continues to grow, you will be expected to hire, mentor and train junior scientists. This largely will be a laboratory-based role, but you also will be able to leverage your excellent communication, problem-solving and organizational skills as an Analytical representative on platform technology and pipeline project teams. As a project representative, you will work closely with teammates in Chemistry, Biology and Bioconjugation to speed the production of ADCs and gain insight to the ADC’s behavior in vivo. Therefore, you will form close partnerships across Mersana and may also work with external collaborators. This will help Mersana to advance new ADCs toward lead candidate status and ultimately, expand its clinical pipeline.

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Senior Scientist, Small Molecule Analytical Development (CMC)

What’s in it for you?

In this role, you’ll have an opportunity to support the analytical characterization and process development activities for Mersana’s ADC pipeline within our CMC Analytical Chemistry group.  This role requires good understanding and expertise in small molecule and polymer analytics.  You’ll also have an opportunity to form close partnerships with CMOs, CROs and internal stakeholders.  If you are passionate about our science and a curious scientist who enjoys being creative and seeking to be professionally challenged, this is a great opportunity to have an impact on Mersana’s unique novel platform.  We will work as a team to expand our knowledge base of our ADCs in order to enable their evolution towards optimized cancer therapies.  You will be immersed in a learning organization, with a need to bring an open mind and an interest in mastering this new therapeutic space at a rapid pace.   As part of a growing company you will have the potential to hire and mentor staff and build processes that will drive innovation, teamwork and efficiency within the organization. 

 

How do you know if you’re the right fit?

The successful and experienced candidate will:

  • Perform RP/IEX/SEC/GPC HPLC and characterization testing of polymer-drug linker intermediates that are a key part of Mersana ADC platform.

  • Spearhead the evaluation/development /qualification of new analytical methodologies to support Mersana ADC pipeline

  • Interact with CROs and CMOs as needed, travel to CRO and CMO sites to represent Mersana Analytical team

  • Schedule, implement method development; maintain accurate laboratory records and notebooks; follow analytical procedures and protocols in compliance with regulatory and safety requirements, contribute to regulatory filings, generate method SOP’s and reports

  • Perform routine maintenance on analytical instrumentation including Shimadzu and Agilent HPLC systems

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BIOCONJUGATION

Senior Scientist, Bioconjugation

What’s in it for you?

In this role, you will have an opportunity to contribute to the advancement of new ADC platform technologies, bioconjugation technologies, and pipeline candidates. Specifically, you will drive innovation and optimization related to the preparation, purification and characterization of novel ADCs for Mersana and its partners.  In this role, you will have the opportunity to initiate, direct and execute scientific research aimed at innovation and bioconjugation process improvements. Your expertise in working with protein conjugates will add value to our team, expanding our knowledge base of our ADCs and enable their timely progression towards breakthrough cancer therapies.  You will be immersed in a learning and team-focused environment, where demonstration of an open mind and interest in mastering this new therapeutic space, and close collaboration with fellow team members are keys to your success. 

 

As part of a growing company, you will have the ability to mentor junior staff.  You will represent Bioconjugation and work closely with teammates in Chemistry, Biology, and Analytical Chemistry, both internally and with collaboration partners, on technology and pipeline teams to advance new technologies and ADCs towards the clinic. 

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CLINICAL DEVELOPMENT

Medical Director/Senior Medical Director, Oncology

What’s in it for you?

As Medical Director/Senior Medical Director, Oncology you’ll be the medical lead for clinical trial(s) for our oncology programs brought forward from our novel ADC platform.  You’ll form close partnerships with Mersana’s cross-functional study teams on preclinical and clinical development including clinical trial strategy, design and execution. To be successful, previous experience as the primary go-to person for strategic planning and execution, including study design and method selection, will be very helpful.  Experience overseeing ongoing medical monitoring of oncology clinical trials will important for your success. 

Typical of this role, you’ll have the opportunity to participate in the development of Study Protocols, IB’s, Clinical Development Plans and other key study documents.  In addition, you’ll have the opportunity for ongoing learning as you participate in the preparation of documentation in support of regulatory submissions including clinical section of IND’s and CTA’s, IND safety reports, annual reports, responses to regulatory authorities and Ethics Committees/IRBs, and other documents. 

 

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CLINICAL OPERATIONS

Clinical Trial Administrator

What’s in it for you?

The successful incumbent will be energized by managing the through-put of data inquires and tracking a myriad of clinical data and information, focusing on laboratory and safety information.  You’ll be able to apply your innate organizational skills to help fine-tune the systematic tracking, distribution, and storage of critical information that develops during the course of clinical trials all while being the information “go-to” person for your colleagues.  Attention to detail, skills for maintaining structured information and data repositories, and a penchant for helping to develop and refine efficient processes, large and small, to stream-line communication of on-going information will be key in this role.  You will love being seen as one of the most organized and pragmatic people at Mersana!

 

  • In this role, you will have an opportunity to be at the front-line of clinical development, handling time-sensitive, emerging, and critical clinical data in multiple drug development programs.
  • You will form close partnerships with Clinical, Data Management, Clinical Pharmacology, and IT professionals at Mersana.
  • Your role will impact Mersana by keeping a team of drug developers fully informed on key, emerging data in a timely and systematic manner.
  • You will also have the opportunity to learn and be part of the development team for implementation of various data handling software solutions such as clinical quality, pharmacovigilance, and laboratory data.
  • To be successful, you will have previously managed clinical and scientific data tracking and filing and understand clinical/medical information. 
  • Initially, this role will report to the head of Clinical Operations. As Mersana grows, this role will require more than one person and the reporting structure will change accordingly.

 

Accurate, ongoing data handling, ensuring corrections are made in a timely fashion, and follow-through with ongoing and growing data sets are all critical elements for the real-time understanding of progress in a drug development program.  The program team will depend on the accuracy and currency of your work when evaluating the effectiveness and execution of their plans.  This role is not a traditional data management position but will work closely with that function.

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Associate Director, Antibody Development and Production

What’s in it for you?

  • At Mersana you will play a leading role in developing robust, cost-effective, and productive antibody production processes.
  • In this role, you will be the principal liaison with Contract Development and Manufacturing Organizations (CDMOs) that are engaged with development and GMP production of mAbs to enable Mersana’s clinical programs. You will leverage both scientific and operational principles to deliver high quality product meeting regulatory expectations, in close collaboration with cell line, purification and analytical development.
  • You will broaden your skills by working cross-functionally within CMC and other areas of the company such as Quality, regulatory, program management, finance, bioconjugation, payload and linker development, formulation, drug product manufacturing, and discovery. In addition, you will have an opportunity to participate in collaborations with Mersana’s corporate partners.
  • This role reports to the Senior Director, Biologics Development.

How do you know if you’re the right fit?

  • You have expertise with state of the art antibody production platforms with a focus on upstream development including small-scale systems, scale-up/scale-down approaches, cell culture modeling and optimization, implementation of feed strategies and the impact of input parameters on titer and product quality. You have championed the introduction of innovations that deliver results.
  • You have substantial experience working with CDMOs in all aspects of antibody production, including project initiation, tech transfer, and GMP manufacturing. You have reviewed and approved protocols, reports and batch records, monitored processes, and participated in troubleshooting issues.
  • You have authored CMC sections of regulatory submissions.
  • You have contributed to the development of project plans including scope, risk assessments, timelines, and resource requirements for several programs.
  • You have lead functional and/or cross functional teams (e.g. CMC) and influenced outcomes, and effectively managed resources.
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CMC DEVELOPMENT

Associate Director/Director, CMC Process Engineering

What’s in it for you?

 

In this role you will have the opportunity to develop and advance Mersana’s Phase 1 pipeline through late stage CMC development and commercialization.  Specifically, you will drive drug substance process engineering to support external scale-up, GMP manufacture, validation and regulatory submission of Mersana’s proprietary Dolaflexin linker technology.  This is a highly inter-disciplinary role where you will interact across all internal CMC functions (Process Chemistry, Analytical, Formulations, Bioconjugation, Quality, Regulatory), as well as leading external Contract Manufacturing Organizations and interacting with Mersana partners who utilize the Dolaflexin technology.  This role offers significant process engineering challenges since the Dolaflexin linker technology straddles both traditional small molecule and biomolecule space and involves techniques and scale up engineering challenges that are distinctly unique.  This position offers an opportunity to learn new techniques and apply innovative approaches to solving unique process manufacturing problems that will have a major impact across all programs that utilize the Dolaflexin technology.  To be successful in this position, you will need to thrive on understanding and analyzing complex process systems and equipment and applying non-traditional approaches to design efficient, reproducible, well controlled and processes that can be validated.   This is a hands-on position that will report to the Executive Director of Drug Substance CMC.  In the future, the position may have direct reports; however, the near-term expectation is that this position will utilize and leverage the resources and expertise of various CDMO’s and CMO’s to drive late stage process development. To be effective, the position will require significant overseas travel for managing CMO’s and being fully immersed in understanding unique manufacturing processes, operations, methods and equipment with an eye toward validation, scale-up and continuous process improvement. In this role, you will be expected to become a Subject Matter Expert on the Dolaflexin manufacturing technology.  However, the Process Engineering function will extend to all compounds that are in the clinical development pipeline.  In this role, you will be expected to build the process engineering function within Mersana that complements and supports CMC development.

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DMPK

Associate Scientist, DMPK/Clinical Pharmacology

What’s in it for you?

In this role, you will have an opportunity to work closely with both clinical and nonclinical peers and grow your experience in DMPK and clinical pharmacology. This role will have a great impact to Mersana at this extraordinary stage of the company’s development, specifically, you will assist in non-clinical & clinical PK, PD data analysis, and spend some of your time interacting with internal and external partners to manage reagents & documents. You will be immersed in a learning organization, where you can bring an open mind and be ready to learn new concepts and tools. 

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INVESTOR & CORPORATE COMMUNICATIONS

Senior/Executive Director, Investor Relations & Corporate Communications

What’s in it for you?

 

In this role, you’ll lead both Mersana’s Investor and Public relations functions.  This role reports into the CFO with a dotted line into our CBO.  As a clinical stage biotech company, you’ll have the opportunity to craft our external communications strategy at a critical time in the business. To be successful, you will have previously held roles of increasing responsibility in either a biotech investor relations function, or a Wall Street firm covering the biotech area. This would be a great role for someone in a public biotech looking for the chance to lead a function, or someone on the coverage side looking to move into the industry.  Either experience in corporate communications or a desire to learn and grow in the area will contribute to success in the role.

 

Key to your success is your ability to:

  • Build Mersana’s in house Investor Relations and Public Relations capabilities
  • Create our roadmap for public relations / external communications directed to our various stakeholders ensuring a thoughtful and consistent multi-year communications strategy.
  • Understand and articulate Mersana’s corporate strategy.  You will need to be able to explain it to external audiences in a clear, concise manner.
  • Leverage prior experience to play a significant role in maintaining and building relationships with our investors while targeting new investors. 
  • Oversee several external vendors who currently contribute greatly to Mersana’s Investor and Public Relations efforts.
  • Learn more broadly about building a biotech company, as our growth trajectory is an important factor in our story to Wall Street and our other external stakeholders
  • Write press / earnings releases and drive the process for executive alignment in the process
  • Develop strategies for community interactions
  • Play a key role in Mersana’s branding, competitive positioning, articulating culture and communicating with employees
  • Form close partnerships with internal and external stakeholders including our executive team, finance, accounting, human resources, clinical development and our scientific leaders. External stakeholders include investors, media, agencies, advocacy groups and scientific bodies.

 

How do you know if you’re the right fit?

You’ll enjoy playing a key role in driving investor relations strategy and in developing messages and a communications plan.  You’ll have had demonstrated success in achieving plan objectives including sell-side targeting, planning road shows, developing content for and executing on plans for special events, attending banking conferences, and in ensuring leaders are prepared for conference calls and meetings.  An ideal candidate will have a significant amount to contribute on day 1 to our IR planning, with the ability and desire to grow into the corporate communications responsibilities.  Experience on the IR side can come from one of several experiences that encompass the IR experience.

Your understanding of various communications platforms will enable you to drive content on our website and tell the right story in the right place.  Your focus and attention to detail will help you build our corporate events calendar, which will coordinate our various external communications efforts.  Your experience will enable you to develop the function while also rolling up your sleeves to manage the content for quarterly financial results, write press releases, provide content for our website, work with Finance and Legal on SEC filings, develop reports and briefings to senior management and BOD, serve as a point of contact for investor and analysts, manage the development and execution of content for quarterly financial results calls, and in developing the annual report and letter to shareholders (10--K wrap). 

Your experience will help us build a multi-year communications plan to serve as a roadmap for our growth.  Additionally, you will be a suburb writer, as this is essential to helping with our internal communications and marketing communications efforts including branding- competitive positioning, employee culture, complicated corporate messaging and in communication with vendors.  As a science driven company, our focus on communications across various scientific venues will be a key driver of success.  Finally, as we grow, your experience leading and mentoring others will be an asset as you help build the Mersana team.

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QUALITY ASSURANCE

Director, QA Operations

What’s in it for you?

  • In this role, you will have an opportunity to build a phase appropriate Quality Management System (QMS)
  • You will make quality decisions that will influence the success and progression of Mersana’s clinical pipeline
  • You will have the opportunity to promote and advance the quality culture at Mersana
  • You will have the opportunity to create an influential and collaborative relationship for Quality across Mersana
  • You will be accountable for the Quality Assurance Operations function and batch decisions for Mersana’s clinical products
  • You will have the opportunity to work with and learn from technical experts internal and external to Mersana through collaboration and partnerships
  • As part of a growing company you will have the ability to mentor staff and build processes that will drive innovation, teamwork and efficiency within the organization
  • To be successful, you must have broad experience in a Quality Assurance role supporting; GLP, GCP, GMP and enjoy working in a fast-paced GxP environment
  • This role reports directly to the Head of Quality. Together, you will promote a culture of quality and operational excellence
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TOXICOLOGY

Director, Investigative Toxicology

What’s in it for you?

In this role, you’ll have the opportunity to lead our early drug development efforts in preclinical safety.  This will have a high impact to Mersana as you focus on Investigative Toxicology and establish and oversee external partnerships with leading CROs with regard to preclinical safety.  You’ll form close partnerships with key counterparts at our collaborators, working with toxicology teams on early safety and investigative toxicology needs.  To be successful you will have previously designed safety studies for  novel drug candidates in oncology and supported drug hunting partners in the identification and optimization of new biologics and small molecule series.  While you’ll have the opportunity to build the function over time, today you’ll serve as Mersana’s internal expert for local discovery, design project-specific strategies to predict, assess and mitigate target-and modality- related safety risks and execute through internal and external experimental capabilities.  

How do you know if you’re the right fit?

Your motivation and experience will enable you to successfully:

  • Interact locally and globally with CROs and with collaborators, including discovery and development toxicology.
  • Develop innovative solutions and research proposals to pursue cutting edge science and technologies to optimize and influence translational safety assessment of novel drug targets and drug candidates.
  • Provide project team input to local discovery project teams for the progression of ADC candidates for regulatory submissions.
  • Engage with experts across the organization to ensure that teams can make the right decisions regarding the translational safety characteristics associated with the project.
  • Continuously interact with multiple R&D functions (Pharmacology, DMPK, Translational Medicine &Early Development, Project Leaders & Managers etc.)
  • Ensure high scientific standards / adhering to requested timelines in all aspects of the position
  • Supervise and develop laboratory staff both internally and at external partners.

 

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