At Mersana, we all share a singular passion and vision: To dramatically improve the lives of people with cancer. We know that what each and every one of us does matters and that our success depends on our ability to work together. We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun. 

If you share our passion to deliver an evolutionary leap in cancer patient care and our drive to tackle difficult challenges in a dynamic and collaborative environment, then please submit your resume or CV to


Principal/Senior Scientist – Protein Characterization ADC - mAb

Mersana has an exciting new opportunity for a Senior/Principal Scientist working with our growing analytical chemistry team.

Key Responsibilities:

  • Responsible for protein analysis and protein characterization working with ADC technology.
  • Perform RP/IEX/SEC HPLC, LC/MS, CE/icIEF and spectrophotometrybased testing of antibodies and antibody-drug conjugates.
  • Perform HPLC and LC/MS analyses and routine maintenance on analytical instrumentation including Shimadzu and Agilent HPLC systems, ThermoFisher Q-Exactive LC MS/MS system.
  • Participate in the development/evaluation of new analytical methods to support our growing drug pipeline and assist our chemistry and bioconjugation groups with their sample preparation and analysis.
  • Development of high throughput methods for screening of antibodies and ADCs for various CQAs
  • Serve as an effective representative of Analytical Chemistry by clear communication, problem-solving and delivering on team goals as a member of Discovery pipeline and technology project teams
  • Schedule, implement method development and research activities; maintain accurate laboratory records and notebooks; follow analytical procedures and validation protocols in compliance with regulatory requirements and industry standards; write analytical reports and SOPs.
  • Develop and qualify new analytical methods for research materials evaluation.
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Associate Director/Director, Antibody Engineering

The Associate Director/Director of Antibody Engineering will be the leader of antibody design and optimization for use in antibody-drug conjugates (ADCs) based on Mersana’s proprietary linker-payload technology. S/he will be work closely with the project teams to define screening cascades, identify lead mAbs, evaluate clinical developability, and optimize sequences; s/he will interface with CROs when needed. S/he will be the key strategist and thought leader on new antibody formats to complement new linker-payload platforms at Mersana. S/he will foster a culture of inclusion, engagement and collaboration in the project teams, the Biology group, and the entire organization.

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Senior Scientist

What’s in it for you?


In this role, you will have an opportunity to contribute to the advancement of new ADC platform technologies, bioconjugation technologies, and pipeline candidates. Specifically, you will drive innovation and optimization related to the preparation, purification and characterization of novel ADCs for Mersana and its partners.  In this role, you will have the opportunity to initiate, direct and execute scientific research aimed at innovation and bioconjugation process improvements. Your expertise in working with protein conjugates will add value to our team, expanding our knowledge base of our ADCs and enable their timely progression towards breakthrough cancer therapies.  You will be immersed in a learning and team-focused environment, where demonstration of an open mind and interest in mastering this new therapeutic space, and close collaboration with fellow team members are keys to your success. 


As part of a growing company, you will have the ability to mentor junior staff.  You will represent Bioconjugation and work closely with teammates in Chemistry, Biology, and Analytical Chemistry, both internally and with collaboration partners, on technology and pipeline teams to advance new technologies and ADCs towards the clinic. 

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Associate Director/Director, Business Development & Licensing

What’s in it for you?

In this role, you will have an opportunity to work closely with Mersana’s leadership and focus on the development and execution of the company’s corporate strategy.  You’ll assist in identifying strategic business opportunities including in-licensing agreements, partnerships, mergers, acquisitions, alliances and/or joint ventures, and then negotiate and review/write the agreements.  You’ll spend much of your time interacting with internal and external partners including outside counsel.  This role will have a great impact to Mersana at this extraordinary stage of the company’s development as you will also work closely with the executive team to support the IR and PR efforts. 

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Head, Discovery Chemistry

Leading by example, s/he will inspire with innovative scientific vision and thought-leadership, promote productive collaboration, and motivate and challenge the research organization to accomplish ambitious goals. S/he will provide thoughtful mentorship and management to a high-caliber research and development team. S/he will be accountable for leading the discovery chemistry team to execute on the pipeline programs and to bring on new discovery programs.

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Associate Scientist, DMPK/Clinical Pharmacology


What’s in it for you?

In this role, you will have an opportunity to work closely with both clinical and nonclinical peers and grow your experience in DMPK and clinical pharmacology. This role will have a great impact to Mersana at this extraordinary stage of the company’s development, specifically, you will assist in non-clinical & clinical PK, PD data analysis, and spend some of your time interacting with internal and external partners to manage reagents & documents. You will be immersed in a learning organization, where you can bring an open mind and be ready to learn new concepts and tools. 

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