Mersana’s innovative platforms are a highly efficient engine that enable us to build a robust discovery pipeline for us and our partners. Our ADCs in preclinical studies and clinical trials are first-in-class molecules that target multiple tumor types with high unmet medical need. We believe our platforms create an opportunity for ADCs with improved safety and efficacy relative to those developed using first-generation technology. Our lead asset, upifitamab rilsodotin (UpRi), is a first-in-class Dolaflexin ADC targeting NaPi2b that is being studied in UPLIFT, a single-arm registrational trial in patients with platinum-resistant ovarian cancer; UPGRADE-A, a Phase 1 trial evaluating UpRi in combination with carboplatin; and UP-NEXT, a Phase 3 clinical trial of UpRi as monotherapy maintenance following treatment with platinum doublets in recurrent platinum-sensitive ovarian cancer. Mersana is also developing XMT-1660, a Dolasynthen ADC targeting B7-H4, and XMT-2056, an Immunosynthen ADC targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). In addition, multiple partners are using Mersana’s platforms to advance their ADC pipelines.

ADC Program	Target	Indication	Platform	Discovery	Preclinical	P1	P1	P2	P3
Clinical
Upifitamab Rilsodotin (UpRi)*	NaPi2b	Platinum-Resistant Ovarian Cancer	Dolaflexin
XMT-1536*	NaPi2b	Recurrent Platinum-Sensitive Ovarian Cancer Maintenance	Dolaflexin
XMT-1536*	NaPi2b	Platinum-Sensitive Ovarian Cancer	Dolaflexin
Discovery
XMT-1660	B7-H4	Multiple Solid Tumors	Dolasynthen
XMT-2056**	Novel HER2 Epitope	Multiple Solid Tumors	Immunosynthen
XMT-2068	Undisclosed	Undisclosed	Immunosynthen
XMT-2175	Undisclosed	Undisclosed	Immunosynthen
Multiple Programs	Undisclosed	Undisclosed	Immunosynthen Dolasynthen Dolaflexin
Collaborators
	Multiple	Undisclosed	Immunosynthen
	Multiple	Undisclosed	Dolasynthen
	Multiple	Undisclosed	Dolaflexin
	5T4	Undisclosed	Dolaflexin

Pipeline

ADC Program	Target	Indication	Platform	Phase
upifitamab rilsodotin (UpRi)*	NaPi2b	Platinum-Resistant Ovarian Cancer	Dolaflexin	P2 Pivotal Study
upifitamab rilsodotin (UpRi)*	NaPi2b	Recurrent Platinum-Sensitive Ovarian Cancer Maintenance	Dolaflexin	P3
upifitamab rilsodotin (UpRi)*	NaPi2b	Platinum-Sensitive Ovarian Cancer	Dolaflexin	P1 Dose Expansion
XMT-1660	B7-H4	Multiple Solid Tumors	Immunosynthen	P1 Dose Escalation
XMT-2056**	Novel HER2 Epitope	Multiple Solid Tumors	Immunosynthen	P1 Dose Escalation
XMT-2068	Undisclosed	Undisclosed	Immunosynthen	Discovery
XMT-2175	Undisclosed	Undisclosed	Immunosynthen	Discovery
Multiple Programs	Undisclosed	Undisclosed	Immunosynthen Dolasynthen Dolaflexin	Preclinical
	Multiple	Undisclosed	Immunosynthen	Discovery
	Multiple	Undisclosed	Dolasynthen	Discovery
	Multiple	Undisclosed	Dolaflexin	Preclinical
	5T4	Undisclosed	Dolaflexin	P1 Dose Escalation

*NaPi2b antibody used in UpRi (formerly XMT-1536) is in-licensed from Recepta Biopharma. Recepta has rights to commercialize UpRi in Brazil.
**XMT-2056 is wholly owned by Mersana, with GSK having an exclusive global license option to co-develop and commercialize the candidate